How to remove a particular character after a specific word

How do I remove the , character after a specific word?

For example, I want to delete the , character after the word IBM

  IBM, Inc.:APP-VM-Core:4.4.2.0:04,

the expected results should be

  IBM Inc.:APP-VM-Core:4.4.2.0:04,

Meanwhile I do the following

   echo “IBM, Inc.:APP-VM-Core:4.4.2.0:04,” | sed s'/,//'

but the problem is that it deletes every , character, no matter what the first word was before the ,. In my case I want to delete the , only after IBM.

Example:

echo "APPLE, Inc.:APP-VM-Core:4.4.2.0:04,"| sed s'/,//'

APPLE Inc.:APP-VM-Core:4.4.2.0:04,

but should be as

APPLE, Inc.:APP-VM-Core:4.4.2.0:04,