adding PATHs for a bunch of programs

I have a big list of programs (samtools,annovar,bra,bedtools etc) in a "Programs" folder.

I have read lots of posts about exporting the path, so that I do not need to identify the whole path to the program from my working folder. However, it still does not work, I guess because I am mixing everything.

There is a perl script in the folder variant_effect_predictor which I want to assess from another folders without typing the whole path to this script.

I am working on OS X. I added to my ~/.profile following:

export PATH=/Users/pics/Desktop/MyDocuments/Programms/ensembl-tools-release-78/scripts/variant_effect_predictor:$PATH

somehow it tells me:

pik:Annotation pic$ perl variant_effect_predictor.pl -custom C0066PH1.H3K4me1.ppqt_macs2_broad_v2.20130819.bed.gz,BED_annotation,BED,overlap,1 -i SNPs_vep_input.txt --cache --force_overwrite --symbol 
Can't open perl script "variant_effect_predictor.pl": No such file or directory

So, the path was not exported or added. How can I fix it?